Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose

Galactose-ƒ¿-1,3-galactose (ƒ¿-gal)-specific IgE test is highly useful for predicting cetuximab-induced anaphylaxis

Background Cetuximab, a chimeric mouse-human IgG1 monoclonal antibody against the epidermal growth factor receptor, is approved for use in colorectal cancer and squamous-cell carcinoma of the head and neck. A high prevalence of hypersensitivity reactions to cetuximab has been reported in some areas of the United States. IgE antibodies against cetuximab were present in the patients with cetuxima...

Galactose-α-1,3-galactose-specific IgE is associated with anaphylaxis but not asthma.

RATIONALE IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose (α-gal) are common in the southeastern United States. These antibodies, which are induced by ectoparasitic ticks, can give rise to positive skin tests or serum assays with cat extract. OBJECTIVES To evaluate the relationship between IgE antibodies to α-gal and asthma, and compare this with the relationship bet...

Delayed mammalian meat-induced anaphylaxis due to galactose-α-1,3-galactose in 5 European patients.

Delayed anaphylaxis to red meat in patients with IgE specific for galactose alpha-1,3-galactose (alpha-gal).

Anaphylaxis is a severe allergic reaction that can be rapidly progressing and fatal. In instances where the triggering allergen is not known, establishing the etiology of anaphylaxis is pivotal to long-term risk management. Our recent work has identified a novel IgE antibody (Ab) response to a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal), that has been associated...

Drug allergens and food--the cetuximab and galactose-α-1,3-galactose story.

OBJECTIVE A novel form of food allergy has been described that initially became apparent from IgE reactivity with the drug cetuximab. Ongoing work regarding the etiology, distribution, clinical management, and cellular mechanisms of the IgE response to the oligosaccharide galactose-α-1,3-galactose (α-gal) is reviewed. DATA SOURCES Brief review of the relevant literature in peer-reviewed journ...